Loss of Endothelial Nitric Oxide Synthase Promotes p25 Generation and Tau Phosphorylation in a Murine Model of Alzheimer’s Disease

Loss of Endothelial Nitric Oxide Synthase Promotes p25 Generation and Tau Phosphorylation in a Murine Model of Alzheimer's Disease.

RATIONALE Alzheimer's disease has an unknown pathogenesis; however, cardiovascular risk factors are associated with a higher incidence of Alzheimer's disease. A defining feature of endothelial dysfunction induced by cardiovascular risk factors is reduced bioavailable endothelial nitric oxide (NO). We previously demonstrated that endothelial NO acts as an important signaling molecule in neuronal...

Association between T-786C polymorphism of endothelial nitric oxide synthase gene and level of the vessel dilation factor in patients with coronary artery disease

Various polymorphisms on endothelial nitric oxide synthase (eNOs) gene cause reduced production of NO, the endothelial relaxing factor, and may accelerate the process of atherosclerosis. The study designed to investigate the frequency of T-786C polymorphism of the eNOs gene in patients suffering from coronary artery disease (CAD) in north-west of Iran. One hundred twenty subjects including 60 p...

Retraction Note: Association between T-786C polymorphism of endothelial nitric oxide synthase gene and level of the vessel dilation factor in patients with coronary artery disease

Untangling Neurons With Endothelial Nitric Oxide

Alzheimer’s disease (AD) is the most prevalent cause of age-related dementia, which, because of demographic shifts and increasing life expectancy, afflicts a growing segment of the world population and is anticipated to reach epidemic proportions in the decades to come. Central to the pathogenesis of AD is the cerebral accumulation of amyloidβ peptides (Aβ) and the microtubule-associated protei...

Untangling Neurons With Endothelial Nitric Oxide.

Alzheimer’s disease (AD) is the most prevalent cause of age-related dementia, which, because of demographic shifts and increasing life expectancy, afflicts a growing segment of the world population and is anticipated to reach epidemic proportions in the decades to come. Central to the pathogenesis of AD is the cerebral accumulation of amyloidβ peptides (Aβ) and the microtubule-associated protei...